CelLBxHealth’s service laboratory provides specialised circulating tumour cell (CTC) enrichment and comprehensive liquid biopsy analysis services
Our mission is to advance the development of new cancer therapies and personalised medicine. We use Parsortix technology to harvest CTCs and CTC clusters for subsequent DNA, RNA and protein expression analysis.
Consult with our scientists to identify the most efficient and effective strategy to meet your project needs
Contact usExpert assay development and custom solutions
Our workflow makes epithelial, mesenchymal and epithelial-mesenchymal transitioning (EMT) CTCs, CTC clusters and cfDNA accessible for downstream analysis. Comprehensive profiling of liquid biopsy samples for drug relevant biomarkers enables longitudinal monitoring of patients and may help to determine:
- Changes in a patient’s biomarker profile over time and in response to treatment
- If the drug is reaching the intended target and inducing the intended response
Our expert team provides a comprehensive solution for the customised analysis of your samples and a service that is tailored to your specifications.
Capabilities include:
Molecular analysis:
- Next generation sequencing (NGS) DNA dual analysis of CTC-DNA and cfDNA from a single blood tube. Our workflow uses CTCs harvested by Parsortix technology combined with Illumina’s Cell-Free DNA Prep with Enrichment kit.
Enumeration, immunofluorescence (IF) and fluorescence in situ hybridisation (FISH):
- Enumeration of epithelial, mesenchymal and epithelial-mesenchymal transitioning (EMT) CTCs and CTC clusters
- DNA Damage Response (DDR) proteins yH2AX, pKAP1 and RAD51, as well as micronuclei detection
- Androgen Receptor protein expression analysis
- PD-L1 protein expression analysis
- Identification of HER2 protein expression by IF and quantification of HER2/neu gene amplification via FISH
We can also undertake bespoke assay development for solid cancers and liquid biopsy applications to meet your specific requirements.
SOC 2®
CelLBxHealth Europe is SOC 2 Type 2 compliant. SOC 2 is an audit standard to evaluate the design and operating effectiveness of controls that meet the AICPA’s Trust Services Principles criteria.
Research Use Only. Not for use in Diagnostic Procedures